Demographic influence on COVID-19 reinfection at the Integrated Laboratory of Syarif Hidayatullah State Islamic University Jakarta

Main Article Content

Fiena Febriyana
Erike A. Suwarsono https://orcid.org/0000-0001-5034-9292

Keywords

demographic, gender, reinfection, COVID-19

Abstract

Background: COVID-19 can reinfect the same person, or it can be called reinfection. Reinfection that occurs has a slightly higher severity level, characterised by the need for ventilation and intensive care in the ICU, than the first infection. This study aimed to determine the influence of demographics on COVID-19 reinfection cases in the Integrated Laboratory of the Faculty of Medicine, Syarif Hidayatullah State Islamic University Jakarta, in 2020-2022.


Methods: The study was an observational analytical study using a cross-sectional design conducted on patients in the Integrated Laboratory of the Faculty of Medicine, Syarif Hidayatullah State Islamic University Jakarta, who were selected by consecutive sampling.


Results: The study aims to understand the relationship between gender, age, occupation, blood type, and source of sample with cases of COVID-19 reinfection. This study collected 396 samples. It was found that the majority of samples had the characteristics of women (57.8%), young adults (35.9%), unknown occupation (45.7%), unknown blood type (39.4%), hospital patients (90.2%), and experienced reinfection (31.8%). The results of the bivariate analysis showed a significant relationship between gender and age with cases of COVID-19 reinfection.


Conclusions: A significant relationship was found between gender and age with cases of COVID-19 reinfection at the Integrated Laboratory of the Faculty of Medicine, Syarif Hidayatullah State Islamic University Jakarta.

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References

1. Dhillon RA, Qamar MA, Gilani JA, et al. The mystery of COVID-19 reinfections: A global systematic review and meta-analysis. Annals of Medicine and Surgery 2021;72:103130.
2. Kemenkes. Covid-19. Infeksi Emerging. 2024;
3. Fergie J, Srivastava A. Immunity to SARS-CoV-2: Lessons Learned. Front Immunol 2021;12.
4. Liu A, Li Y, peng J, Huang Y, Xu D. Antibody responses against SARS‐CoV‐2 in COVID‐19 patients. J Med Virol 2021;93(1):144–148.
5. To K, Hung I, Chan K. Serum antibody profile of a patient with COVID-19 reinfection. Clin Infect Dis 2021;72(10):e659–e662.
6. Arkhipova-Jenkins I, Helfand M, Armstrong C, et al. Antibody Response After SARS-CoV-2 Infection and Implications for Immunity. Ann Intern Med 2021;174(6):811–821.
7. Iyer AS, Jones FK, Nodoushani A, et al. Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients. Sci Immunol 2020;5(52).
8. Costa AOC, Carvalho Aragão Neto H de, Lopes Nunes AP, Dias de Castro R, Nóbrega de Almeida R. COVID-19: Is reinfection possible? EXCLI J 2021;20:522–536.
9. Almadhi M, Alsayyad AS, Conroy R, et al. Epidemiological assessment of SARS-CoV-2 reinfection. International Journal of Infectious Diseases 2022;123:9–16.
10. Su S, Jiang Z, Shi L, et al. Physical, cognitive, and mental health impacts of Omicron reinfection in patients with original SARS-CoV-2 infection: a community-based observational study. BMC Med 2025;23(1):526.
11. Meng M, Wei R, Wu Y, et al. Long-term risks of respiratory diseases in patients infected with SARS-CoV-2: a longitudinal, population-based cohort study. EClinicalMedicine 2024;69:102500.
12. Galbadage T, Peterson BM, Awada J, et al. Systematic Review and Meta-Analysis of Sex-Specific COVID-19 Clinical Outcomes. Front Med (Lausanne) 2020;7.
13. Gebhard C, Regitz-Zagrosek V, Neuhauser HK, Morgan R, Klein SL. Impact of sex and gender on COVID-19 outcomes in Europe. Biol Sex Differ 2020;11(1):29.
14. Yang J, Zheng Y, Gou X, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. International Journal of Infectious Diseases 2020;94:91–95.
15. Bechmann N, Barthel A, Schedl A, et al. Sexual dimorphism in COVID-19: potential clinical and public health implications. Lancet Diabetes Endocrinol 2022;10(3):221–230.
16. Ahmed SB, Dumanski SM. Sex, gender and COVID-19: a call to action. Canadian Journal of Public Health 2020;111(6):980–983.
17. Francia S De, Ferretti A, Chiara F, et al. The Influence of Sex, Gender, and Age on COVID-19 Data in the Piedmont Region (Northwest Italy): The Virus Prefers Men. Life 2022;12(5):643.
18. Wu Y, Feng Z, Li P, Yu Q. Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19. Clinica Chimica Acta 2020;509:220–223.
19. Tang X, Musa SS, Zhao S, He D. Reinfection or Reactivation of Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review. Front Public Health 2021;9.
20. Pinto LM, Nanda V, Sunavala A, Rodriques C. Reinfection in COVID-19: A scoping review. Med J Armed Forces India 2021;77:S257–S263.
21. Li C, Zhou T, Zhang P, He J, Liu Y. Investigation of epidemiological and clinical characteristics of people infected with SARS-CoV-2 during the second pandemic of COVID-19 in Chengdu, China. Front Public Health 2024;12.
22. Davies NG, Klepac P, Liu Y, et al. Age-dependent effects in the transmission and control of COVID-19 epidemics. Nat Med 2020;26(8):1205–1211.
23. Zhang J, Litvinova M, Liang Y, et al. Changes in contact patterns shape the dynamics of the COVID-19 outbreak in China. Science (1979) 2020;368(6498):1481–1486.
24. Adrielle dos Santos L, Filho PG de G, Silva AMF, et al. Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers. Journal of Infection 2021;82(3):399–406.
25. Zavaleta-Monestel E, Rojas-Chinchilla C, Anchía-Alfaro A, et al. Tracking the Threat, 50 Years of Laboratory-Acquired Infections: A Systematic Review. Acta Microbiologica Hellenica 2025;70(2):11.
26. Chia PY, Sengupta S, Kukreja A, S.L. Ponnampalavanar S, Ng OT, Marimuthu K. The role of hospital environment in transmissions of multidrug-resistant gram-negative organisms. Antimicrob Resist Infect Control 2020;9(1):29.