Post-Bronchoscopy Infections: A Literature Review A Literature Review
Main Article Content
Keywords
post-bronchoscopy, infection, microorganism
Abstract
Post-bronchoscopy infections are a critical concern in respiratory medicine, given their potential to exacerbate patient morbidity, particularly among immunocompromised individuals or those with pre-existing lung conditions, one of which is infection. The infection arises from lower respiratory tract pathogens, and most infections originate from reprocessing practices. Infection can occur when the bronchoscope comes into contact with the mucosa and blood vessels of the respiratory tract. Bacteremia is a more often post-bronchoscopy infection complication rather than pneumonia. It is commonly involving Coagulase-negative or positive Staphylococcus, non-hemolytic or hemolytic Streptococcus, Citrobacter species, and Klebsiella. However, in general, the incidence of post-bronchoscopy infection is mainly caused by gram-negative bacteria. Various risks can affect post-bronchoscopy infection that can increase the severity of the disease to death. It is important to increase obedience and precaution against the transmission of infection. Reducing bacterial pathogens and controlling infection are important steps to reduce the post-bronchoscopy infection mortality rate. Therefore, this study aimed to review the post-bronchoscopy infections in detail.
References
2. Becker HD. A Short History of Flexible Bronchoscopy. In: Flexible Bronchoscopy. Wiley; 2020. p. 1–19.
3. Sato Y, Murata K, Yamamoto M, Ishiwata T, Kitazono-Saitoh M, Wada A, et al. Risk factors for post-bronchoscopy pneumonia: a case-control study. Sci Rep. 2020;10(1):19983. Available from: https://pubmed.ncbi.nlm.nih.gov/33204000
4. Mehta AC, Prakash UBS, Garland R, Haponik E, Moses L, Schaffner W, et al. American College of Chest Physicians and American Association for Bronchology [corrected] consensus statement: prevention of flexible bronchoscopy-associated infection. Chest. 2005;128(3):1742–55. Available from: https://pubmed.ncbi.nlm.nih.gov/16162783
5. Barron SP, Kennedy MP. Single-Use (Disposable) Flexible Bronchoscopes: The Future of Bronchoscopy? Adv Ther. 2020/09/17. 2020;37(11):4538–48. Available from: https://pubmed.ncbi.nlm.nih.gov/32944885
6. Du Rand IA, Blaikley J, Booton R, Chaudhuri N, Gupta V, Khalid S, et al. British Thoracic Society guideline for diagnostic flexible bronchoscopy in adults: accredited by NICE. Thorax. 2013;68(Suppl 1):i1–44. Available from: http://dx.doi.org/10.1136/thoraxjnl-2013-203618
7. Steinfort DP, Johnson DF, Irving LB. Incidence of bacteraemia following endobronchial ultrasound-guided transbronchial needle aspiration. European Respiratory Journal. 2009;36(1):28–32. Available from: http://dx.doi.org/10.1183/09031936.00151809
8. Galdys AL, Marsh JW, Delgado E, Pasculle AW, Pacey M, Ayres AM, et al. Bronchoscope-associated clusters of multidrug-resistant Pseudomonas aeruginosa and carbapenem-resistant Klebsiella pneumoniae. Infect Control Hosp Epidemiol. 2019;40(1):40–6.
9. Aguñín PR. Infectious complications following bronchoscopy: does sedation play a role? Journal of Lung, Pulmonary & Respiratory Research. 2018;5(4):112–8. Available from: http://dx.doi.org/10.15406/jlprr.2018.05.00174
10. Shimoda M, Yamana K, Yano R, Saitou M, Fujiwara K, Furuuchi K, et al. Analysis of risk factors for the development of a post-bronchoscopy respiratory infection in lung cancer patients. Journal of Infection and Chemotherapy. 2021;27(2):237–42.
11. Agrawal A, Murgu S. Infections After Radial EBUS-Guided Transbronchial Lung Biopsy. Chest. 2020;158(2):458–60. Available from: http://dx.doi.org/10.1016/j.chest.2020.04.030
12. Asano Y, Kashiwagi S, Onoda N, Noda S, Kawajiri H, Takashima T, et al. Platelet–Lymphocyte Ratio as a Useful Predictor of the Therapeutic Effect of Neoadjuvant Chemotherapy in Breast Cancer. PLoS One. 2016;11(7):e0153459.
13. Yu G, Dymond M, Yuan L, Chaturvedi LS, Shiratsuchi H, Durairaj S, et al. Propofol’s effects on phagocytosis, proliferation, nitrate production, and cytokine secretion in pressure-stimulated microglial cells. Surgery. 2011/06/15. 2011;150(5):887–96. Available from: https://pubmed.ncbi.nlm.nih.gov/21676422
14. Sharif-Kashani B, Raeissi S, Bikdeli B, Shahabi P, Behzadnia N, Saliminejad L, et al. Sticker reminders improve thromboprophylaxis appropriateness in hospitalized patients. Thromb Res. 2010;126(3):211–6. Available from: http://dx.doi.org/10.1016/j.thromres.2010.05.020
15. Wang K-P, Mehta AC, Turner JF. Flexible Medical Bronchoscopy. 4th ed. Willey Blackwell; 2020. 1–479 p.
16. Rounds S, Dixon A, Schnapp L, Huang Y. The Microbiomein Respiratory Disease. Huang YJ, Garantziotis S, editors. Human Press; 2022. 21–21 p.
17. Culver DA, Gordon SM, Mehta AC. Infection Control in the Bronchoscopy Suite. Am J Respir Crit Care Med. 2003;167(8):1050–6. Available from: http://dx.doi.org/10.1164/rccm.200208-797cc
18. Srinivasan A, Wolfenden LL, Song X, Mackie K, Hartsell TL, Jones HD, et al. An Outbreak ofPseudomonas aeruginosaInfections Associated with Flexible Bronchoscopes. New England Journal of Medicine. 2003;348(3):221–7. Available from: http://dx.doi.org/10.1056/nejmoa021808
19. Thi MTT, Wibowo D, Rehm BHA. Pseudomonas aeruginosa Biofilms. Int J Mol Sci. 2020;21(22):8671. Available from: https://pubmed.ncbi.nlm.nih.gov/33212950
20. Hackner K, Riegler W, Handzhiev S, Bauer R, Veres J, Speiser M, et al. Fever after bronchoscopy: serum procalcitonin enables early diagnosis of post-interventional bacterial infection. BMC Pulm Med. 2017;17(1):156. Available from: https://pubmed.ncbi.nlm.nih.gov/29179755
21. Park JS, Lee C-H, Yim J-J, Yang S-C, Yoo C-G, Chung HS, et al. Impact of antibiotic prophylaxis on postbronchoscopy fever: a randomised controlled study. The International Journal of Tuberculosis and Lung Disease. 2011;15(4):528–35. Available from: http://dx.doi.org/10.5588/ijtld.10.0386
22. Souma T, Minezawa T, Yatsuya H, Okamura T, Yamatsuta K, Morikawa S, et al. Risk Factors of Infectious Complications After Endobronchial Ultrasound-Guided Transbronchial Biopsy. Chest. 2020;158(2):797–807. Available from: http://dx.doi.org/10.1016/j.chest.2020.02.025
23. Wacker C, Prkno A, Brunkhorst FM, Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis. 2013;13(5):426–35. Available from: http://dx.doi.org/10.1016/s1473-3099(12)70323-7
24. Rhee C. Using Procalcitonin to Guide Antibiotic Therapy. Open Forum Infect Dis. 2016;4(1):ofw249–ofw249. Available from: https://pubmed.ncbi.nlm.nih.gov/28480245
25. Schuetz P, Beishuizen A, Broyles M, Ferrer R, Gavazzi G, Gluck EH, et al. Procalcitonin (PCT)-guided antibiotic stewardship: an international experts consensus on optimized clinical use. Clinical Chemistry and Laboratory Medicine (CCLM). 2019;57(9):1308–18. Available from: http://dx.doi.org/10.1515/cclm-2018-1181
26. Farrokhpour M, Kiani A, Mortaz E, Taghavi K, Farahbod AM, Fakharian A, et al. Procalcitonin and Proinflammatory Cytokines in Early Diagnosis of Bacterial Infections after Bronchoscopy. Open Access Maced J Med Sci. 2019;7(6):913–9. Available from: https://pubmed.ncbi.nlm.nih.gov/30976333
27. Harbarth S, Holeckova K, Froidevaux C, Pittet D, Ricou B, Grau GE, et al. Diagnostic Value of Procalcitonin, Interleukin-6, and Interleukin-8 in Critically Ill Patients Admitted with Suspected Sepsis. Am J Respir Crit Care Med. 2001;164(3):396–402. Available from: http://dx.doi.org/10.1164/ajrccm.164.3.2009052
28. Gilbert DN. Use of plasma procalcitonin levels as an adjunct to clinical microbiology. J Clin Microbiol. 2010/04/26. 2010;48(7):2325–9. Available from: https://pubmed.ncbi.nlm.nih.gov/20421436
29. Wong JL, Evans SE. Bacterial Pneumonia in Patients with Cancer: Novel Risk Factors and Management. Clin Chest Med. 2017/03/01. 2017;38(2):263–77. Available from: https://pubmed.ncbi.nlm.nih.gov/28477638
30. ASANO F, AOE M, OHSAKI Y, OKADA Y, SASADA S, SATO S, et al. Deaths and complications associated with respiratory endoscopy: A survey by the Japan Society for Respiratory Endoscopy in 2010. Respirology. 2012;17(3):478–85. Available from: http://dx.doi.org/10.1111/j.1440-1843.2011.02123.x
31. Takiguchi H, Hayama N, Oguma T, Harada K, Sato M, Horio Y, et al. Post-bronchoscopy pneumonia in patients suffering from lung cancer: Development and validation of a risk prediction score. Respir Investig. 2017;55(3):212–8. Available from: http://dx.doi.org/10.1016/j.resinv.2016.12.007
32. Okachi S, Imaizumi K, Imai N, Shimizu T, Hase T, Morise M, et al. Safety and efficacy of diagnostic flexible bronchoscopy in very old patients with lung cancer. Eur Geriatr Med. 2018;9(2):255–62. Available from: http://dx.doi.org/10.1007/s41999-018-0033-7
33. Fortin M, Taghizadeh N, Chee A, Hergott CA, Dumoulin E, Tremblay A, et al. Lesion heterogeneity and risk of infectious complications following peripheral endobronchial ultrasound. Respirology. 2016;22(3):521–6. Available from: http://dx.doi.org/10.1111/resp.12942
34. Hiraishi Y, Izumo T, Sasada S, Matsumoto Y, Nakai T, Tsuchida T, et al. Factors affecting bacterial culture positivity in specimens from bronchoscopy in patients with suspected lung cancer. Respir Investig. 2018;56(6):457–63. Available from: http://dx.doi.org/10.1016/j.resinv.2018.07.006
35. Rolston KVI, Nesher L. Post-Obstructive Pneumonia in Patients with Cancer: A Review. Infect Dis Ther. 2018/02/01. 2018;7(1):29–38. Available from: https://pubmed.ncbi.nlm.nih.gov/29392577
36. Garcia LS, Isenberg HD, editors. Clinical Microbiology Procedures Handbook. Wiley; 2010.
37. Carroll KC, Hobden JA, Miller S, Morse SA, Mietzner TA, Detrick B, et al. Adelberg’s Medical Microbiology [Internet]. Vol. 20, Indian Journal of Medical Microbiology. Elsevier BV; 2019. 1–231 p. Available from: http://dx.doi.org/10.1016/s0255-0857(21)03203-5
38. Kawasaki T, Nakagawa N, Murata M, Yasuo S, Yoshida T, Ando K, et al. Diagnostic accuracy of urinary antigen tests for legionellosis: A systematic review and meta-analysis. Respir Investig. 2022;60(2):205–14. Available from: http://dx.doi.org/10.1016/j.resinv.2021.11.011
39. Huh HJ, Kim JY, Kwon HJ, Yun SA, Lee MK, Ki CS, et al. Performance Evaluation of the PowerChek MERS (upE & ORF1a) Real-Time PCR Kit for the Detection of Middle East Respiratory Syndrome Coronavirus RNA. Ann Lab Med. 2017;37(6):494–8. Available from: https://pubmed.ncbi.nlm.nih.gov/28840986
40. Calderaro A, Buttrini M, Farina B, Montecchini S, De Conto F, Chezzi C. Respiratory Tract Infections and Laboratory Diagnostic Methods: A Review with A Focus on Syndromic Panel-Based Assays. Microorganisms. 2022;10(9):1856. Available from: https://pubmed.ncbi.nlm.nih.gov/36144458
41. Kanazawa H. Efficacy of azithromycin administration in prevention of respiratory tract infection after bronchoscopic biopsy: A randomized, controlled trial. Respirology. 2006;12(1):70–5. Available from: http://dx.doi.org/10.1111/j.1440-1843.2006.00973.x
42. Siegel JD, Rhinehart E, Jackson M, Chiarello L. Management of multidrug-resistant organisms in health care settings, 2006. Am J Infect Control. 2007;35(10):S165–93. Available from: http://dx.doi.org/10.1016/j.ajic.2007.10.006
43. Rutala WA. APIC guideline for selection and use of disinfectants. Am J Infect Control. 1996;24(4):313–42. Available from: http://dx.doi.org/10.1016/s0196-6553(96)90066-8
44. Leers WD. Disinfecting endoscopes: how not to transmit Mycobacterium tuberculosis by bronchoscopy. Can Med Assoc J. 1980;123(4):275–80, 283.
45. Lamb CR, Yavarovich E, Kang V, Servais EL, Sheehan LB, Shadchehr S, et al. Performance of a new single-use bronchoscope versus a marketed single-use comparator: a bench study. BMC Pulm Med. 2022;22(1):189. Available from: https://pubmed.ncbi.nlm.nih.gov/35550062
46. Farrokhpour M, Kiani A, Mortaz E, Taghavi K, Farahbod AM, Fakharian A, et al. Procalcitonin and Proinflammatory Cytokines in Early Diagnosis of Bacterial Infections After Bronchoscopy. Open Access Maced J Med Sci. 2019;7(6):913–9.